มีการรายงานว่านักแสดงหนุ่มสุดป่วน(ทั้งภายในและนอกจอ)ชื่อดัง อย่าง ไรอัน เรย์โนลส์ (Ryan Reynolds) ที่เคยฝากผลงานการแสดงในบทซูเปอร์ฮีโร่สุดกวนมาแล้วใน Deadpool ได้ถูกตั้งเป็นตัวเลือกแรกให้เข้ามาแจมหนังซอมบี้สุดฮาภาคต่ออย่าง Zombieland 2 Double Tap ในบทตัวละครหลักอย่าง Albuquerque ที่จะต้องประฝีปากกับ Woody Harrelson!
Paul Wernick ผู้เขียนบท Zombieland 2 อีกทั้งเขายังเป็นผู้เขียนบท Deadpool และ Deadpool 2 ซึ่งพูดได้ว่าเป็นผู้ที่เคยร่วมงานกับไรอันมาก่อน ได้บอกกับสื่อ Deadline เกี่ยวกับแผนดั้งเดิมที่เขาตั้งใจจะดึงตัว ไรอัน เรย์โนลส์ เข้ามาร่วมโปรเจ็ค แต่กลับไม่เป็นผลสำเร็จเนื่องจากปัญหาตารางเวลาที่ ไรอัน ต้องการใช้เวลาอยู่กับครอบครัวมากกว่า ดังนั้นบท Albuquerque จึงถูกส่งต่อให้ Luke Wilson แทน
Paul Wernick พูดขำๆว่า “เรามีจุดมุ่งหมายสูงสุดคือการทำแค่เพียงหนังเดี่ยวของ ไรอัน เรย์โนลส์ ครับ” ก่อนที่เขาจะเสริมว่า “แต่สำหรับเรื่องนี้มันกลับหลุดรอดเงื้อมมือเราไปซะได้. Luke คือคนที่มหัศจรรย์และมันก็เป็นสิ่งที่สุดยอดมากสำหรับเราครับ”
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